Peptidchem signaling peptide hexapeptide-10 powder supplier (Serilesine, CAS 146439-94-3) for global cosmetic manufacturers. Available in bulk quantities with GMP production, COA, MSDS, and customized packaging support.
What is Hexapeptide-10 Powder?
Hexapeptide-10 is a synthetic bioactive hexapeptide composed of six amino acids with the sequence Ser-Ile-Lys-Val-Ala-Val (SIKVAV). It is derived from the functional adhesion sequence of laminin and belongs to the category of signaling peptides used in advanced anti-aging skincare formulations.
As a cosmetic signaling peptide ingredient, Hexapeptide-10 is designed to support the appearance of skin firmness, elasticity, and structural integrity by targeting the dermal-epidermal junction (DEJ). It is widely used in premium anti-aging creams, serums, facial masks, eye-care products, and professional skincare formulations.
Peptidchem provides cosmetic-grade Hexapeptide-10 Powder with high purity, stable supply capacity, complete documentation, and global export services.
What is Source of Hexapeptide-10？
| Item | Information |
|---|---|
| Source | Synthetic peptide produced by solid-phase peptide synthesis (SPPS) |
| Origin | Controlled pharmaceutical/cosmetic peptide manufacturing process |
| Raw Materials | Protected amino acids and peptide synthesis reagents |
| Application Grade | Cosmetic Grade |
| Form | White to off-white powder |
| Manufacturing Standard | GMP-controlled production environment |
Manufacturing Process of Hexapeptide-10 Powder
Peptidchem Hexapeptide-10 Powder is manufactured using advanced solid-phase peptide synthesis (SPPS) technology.
1.Amino Acid Preparation
High-purity protected amino acids are selected according to the target peptide sequence.
2.Solid Phase Peptide Assembly
Amino acids are sequentially coupled onto a resin carrier following the SIKVAV sequence:
Ser → Ile → Lys → Val → Ala → Val
3.Deprotection and Cleavage
Protective groups are removed, and the peptide chain is cleaved from the resin.
4.Purification
Advanced purification technologies including preparative HPLC are used to remove impurities and by-products.
5.Identification & Quality Testing
Each batch undergoes:
- HPLC purity testing
- Mass spectrometry identification
- Residual solvent analysis
- Heavy metal testing
- Microbial testing
6.Freeze Drying
The purified peptide solution is lyophilized into stable powder form.
Hexapeptide-10 Powder Cosmetic Specification
| Test Item | Specification |
|---|---|
| Product Name | Hexapeptide-10 Powder |
| INCI Name | Hexapeptide-10 |
| Other Name | Serilesine / SIKVAV Peptide |
| CAS Number | 146439-94-3 |
| Appearance | White to off-white powder |
| Odor | Characteristic peptide odor |
| Peptide Sequence | Ser-Ile-Lys-Val-Ala-Val |
| Molecular Formula | C28H53N7O8 |
| Molecular Weight | 615.77 g/mol |
| Purity (HPLC) | ≥95% / ≥98% available |
| Identification (MS) | Conforms |
| Solubility | Water soluble |
| Water Content | ≤8% |
| Heavy Metals | ≤10 ppm |
| Lead (Pb) | ≤3 ppm |
| Arsenic (As) | ≤2 ppm |
| Mercury (Hg) | ≤1 ppm |
| Total Plate Count | Complies |
| Yeast & Mold | Complies |
| Storage Condition | 2–8°C, dry and protected from light |
| Shelf Life | 24 months |
Hexapeptide-10 Powder for Cosmetics Formula Solutions
Hexapeptide-10 (Serilesine / SIKVAV peptide) is a cosmetic signaling peptide mainly used in anti-aging, skin-firming, skin-restructuring, and premium peptide skincare formulations. It is typically incorporated at low concentrations because of its high biological activity. Technical supplier data commonly recommend 0.005% use level with a maximum around 0.05%, added during the cooling phase below 45°C and within a suitable pH range.
1.Anti-Aging Firming Peptide Serum
| Ingredient | INCI Name | Percentage (%) | Function |
|---|---|---|---|
| Deionized Water | Aqua | 76.50 | Solvent |
| Glycerin | Glycerin | 5.00 | Humectant |
| Propanediol | Propanediol | 5.00 | Moisturizer / Solvent |
| Sodium Hyaluronate | Sodium Hyaluronate | 0.20 | Hydration |
| Niacinamide | Niacinamide | 3.00 | Skin conditioning |
| Panthenol | Panthenol | 1.00 | Soothing agent |
| Hexapeptide-10 Powder | Hexapeptide-10 | 0.05 | Firming peptide active |
| Carbomer | Carbomer | 0.30 | Thickener |
| Arginine | Arginine | 0.30 | pH adjustment |
| Preservative System | Phenoxyethanol / Ethylhexylglycerin | 1.00 | Preservation |
| Fragrance | Parfum | 0.05 | Sensory |
| Water | Aqua | q.s. to 100 | Balance |
2.Anti-Aging Firming Cream
| Ingredient | INCI Name | Percentage (%) | Function |
|---|---|---|---|
| Water | Aqua | 68.00 | Solvent |
| Shea Butter | Butyrospermum Parkii Butter | 5.00 | Emollient |
| Caprylic/Capric Triglyceride | CCT | 8.00 | Skin conditioning |
| Squalane | Squalane | 3.00 | Barrier support |
| Glyceryl Stearate | Glyceryl Stearate | 3.00 | Emulsifier |
| Cetearyl Alcohol | Cetearyl Alcohol | 2.00 | Texture modifier |
| Niacinamide | Niacinamide | 3.00 | Brightening / conditioning |
| Hydrolyzed Collagen | Hydrolyzed Collagen | 1.00 | Skin conditioning |
| Hexapeptide-10 Powder | Hexapeptide-10 | 0.05 | Firming peptide |
| Sodium Hyaluronate | Sodium Hyaluronate | 0.20 | Hydration |
| Preservative | Preservative Blend | 1.00 | Protection |
| Water | Aqua | q.s. | Balance |
3.Eye Contour Peptide Gel
| Ingredient | Percentage (%) | Function |
|---|---|---|
| Purified Water | 82.00 | Base |
| Glycerin | 4.00 | Hydration |
| Betaine | 3.00 | Moisturizing |
| Caffeine | 1.00 | Eye-area care |
| Sodium Hyaluronate | 0.20 | Hydration |
| Hexapeptide-10 | 0.03 | Firming peptide |
| Acetyl Tetrapeptide-5 | 0.05 | Eye-area peptide |
| Carbomer | 0.25 | Gel structure |
| Preservative | 1.00 | Stability |
| Water | q.s. | Balance |
Hexapeptide-10 vs GHK-Cu: Which Peptide Is Better for Anti-Aging Skincare
Hexapeptide-10 focuses on skin structural signaling and dermal-epidermal junction support, while GHK-Cu is widely recognized for copper-dependent skin repair pathways.
For premium anti-aging formulas:
- Hexapeptide-10 → firmness, density, structural support
- GHK-Cu → repair, regeneration, collagen-related applications
Many advanced formulations combine multiple peptides for complementary benefits.
Hexapeptide-10 vs Palmitoyl Pentapeptide-4
| Feature | Hexapeptide-10 | Palmitoyl Pentapeptide-4 |
|---|---|---|
| Category | Signal peptide | Matrix peptide |
| Main Target | Skin adhesion structure | Collagen signaling |
| Best For | Firmness | Wrinkle reduction |
| Formula Position | Premium anti-aging | Daily anti-wrinkle |
Hexapeptide-10 vs Other Cosmetic Peptides
| Ingredient | Main Function | Target Area | Typical Application |
|---|---|---|---|
| Hexapeptide-10 | Skin structure signaling | Dermal-epidermal junction | Firming & anti-aging |
| Copper Tripeptide-1 (GHK-Cu) | Repair & regeneration support | ECM remodeling | Repair serums |
| Palmitoyl Pentapeptide-4 | Collagen-support peptide | Fine lines | Anti-wrinkle creams |
| Acetyl Hexapeptide-8 | Expression wrinkle peptide | Facial muscles | Botox-like skincare |
| Palmitoyl Tripeptide-1 | Matrix signaling | Collagen pathway | Anti-aging formulas |
Why Choose Peptidchem?
Peptidchem specializes in the manufacturing and global supply of high-quality cosmetic peptide, providing complete solutions from peptide synthesis to international delivery.
1. Advanced Peptide Manufacturing Platform
Our factory uses:
- Solid-phase peptide synthesis technology
- High-performance purification systems
- Advanced analytical instruments
to ensure consistent peptide quality.
2. Strict Quality Control
Every batch includes:
- COA
- HPLC chromatogram
- MS testing
- TDS
- MSDS
- Stability data
3. Bulk Export Capability
We support:
- Small R&D quantities
- Kilogram-scale production
- OEM cosmetic manufacturers
- Global distributors
4. Customized Services
Available services:
- Customized purity requirements
- Customized packaging
- Private labeling support
- Formula development assistance
5. Global Compliance Support
Documentation support for:
- USA cosmetic brands
- EU skincare manufacturers
- Asian beauty companies
- International distributors
Peptidchem can supply bulk Hexapeptide-10 Powder with customized active specifications, formulation support, COA documentation, and export-ready quality systems. Contact us today!
