Waht is S-Equol?
S-equol bulk powder is a high-purity, bioactive isoflavone metabolite derived from soy daidzein through fermentation. Known for its potent antioxidant properties, S-equol is widely used in dietary supplements, functional foods, and cosmetic formulations. It supports hormonal balance, promotes skin health, and is recognized for its role in menopausal wellness and overall health maintenance.
S-Equol Manufacturing Process
Raw Material Selection: High-quality soy isoflavones sourced from certified suppliers.
Purification: Extraction and concentration of daidzein.
Fermentation: Controlled fermentation with proprietary probiotic strains to convert daidzein into S-equol.
Filtration & Drying: Microfiltration and vacuum drying to maintain purity and stability.
Quality Testing: HPLC, microbiological, and heavy metal analysis to ensure compliance with international standards.
S-Equol Powder Specifications
| Parameter |
Specification |
| Appearance |
White to off-white fine powder |
| Purity (HPLC) |
≥ 98% |
| Solubility |
Soluble in ethanol, DMSO; slightly soluble in water |
| Loss on Drying |
≤ 3% |
| Heavy Metals |
Pb ≤ 2ppm, As ≤ 1ppm, Cd ≤ 1ppm, Hg ≤ 0.1ppm |
| Microbial Limit |
Total Plate Count ≤ 1000 CFU/g, Yeast & Mold ≤ 100 CFU/g |
| Particle Size |
80–120 mesh |
| Grade |
Food-grade / Cosmetic-grade |
S-Equol Powder to Supplements & Cosmetic Solutions
1.S-Equol in Anti-aging Skincare Formulations
| Product Type |
Recommended S-equol Concentration |
Base / Carrier |
Emulsifier / Solubilizer |
pH |
Notes / Application Tips |
| Facial Cream |
0.1% – 0.5% |
Water-in-oil or oil-in-water cream |
Polysorbate 60, PEG-40 hydrogenated castor oil |
5.0 – 6.5 |
Add S-equol to oil phase for better solubility and stability |
| Serum / Ampoule |
0.2% – 1% |
Hydroalcoholic solution / serum base |
Ethanol, Propylene glycol, DMSO (cosmetic-grade) |
5.5 – 6.0 |
Mix S-equol fully in solvent before adding other actives |
| Lotion / Body Cream |
0.05% – 0.3% |
Lightweight oil-in-water lotion |
Polysorbate 20, Lecithin |
5.0 – 7.0 |
Ensure gentle mixing to avoid destabilizing emulsions |
| Sheet Mask / Gel |
0.1% – 0.5% |
Hydrogel or alginate gel base |
Glycerin, Propylene glycol |
5.0 – 6.5 |
Dissolve S-equol in solvent before gel incorporation |
| Eye Cream / Delicate Areas |
0.05% – 0.2% |
Soft cream or emulsion base |
Polysorbate 60, PEG-40 |
5.0 – 6.0 |
Lower concentration for sensitive skin areas |
| Hair & Scalp Serum |
0.1% – 0.5% |
Lightweight oil or hydroalcoholic base |
Ethanol, Propylene glycol |
5.5 – 6.5 |
Supports scalp antioxidant protection and hair follicle health |
*Notes for Formulators
Stability: Avoid strong oxidizers and high heat; store finished products at 4–25°C for best shelf life.
Compatibility: S-equol is stable with most cosmetic excipients but may degrade under extreme pH (<4 or >7).
Safety: Cosmetic-grade S-equol is non-toxic, non-irritant, and hypoallergenic within recommended dosage. Patch testing is recommended for sensitive skin.
Solubility Tip: Dissolve S-equol in ethanol, DMSO, or glycol-based solvents before adding to water-based formulations.
2.S-Equol in Women Menopausal Supplements Formulations
| Parameter |
Capsules |
Gummies |
Notes / Safety Information |
| Ingredient |
S-equol Powder ≥98% purity |
S-equol Powder ≥98% purity |
Food-grade, female-focused functional ingredient |
| Recommended Dosage per Serving |
10–25 mg per capsule |
10–25 mg per gummy |
Typical range for menopausal support and hormonal balance |
| Formulation Type |
Hard capsules, soft capsules |
Gelatin or pectin-based gummies |
Can combine with vitamins, minerals, or botanical extracts |
| Excipients / Carriers |
Microcrystalline cellulose, magnesium stearate, silicon dioxide |
Sugar, glucose syrup, pectin, citric acid, flavoring |
Supports powder flow and stability for capsules; texture and taste for gummies |
| Solubility |
Slightly soluble in water; soluble in ethanol |
Slightly soluble in water; soluble in gelatin or pectin matrix |
May use microencapsulation to improve dispersion and stability |
| Target Application |
Menopausal health, hormonal balance, antioxidant support |
Menopausal health, hormonal balance, antioxidant support |
Female-focused dietary supplements |
| Stability Conditions |
Stable at 4–40°C, low humidity |
Stable at 15–25°C, low humidity |
Avoid direct sunlight and high heat |
| Safety Profile |
Non-toxic, hypoallergenic |
Non-toxic, hypoallergenic |
Recommended adult use; patch test or taste testing for gummies |
| Regulatory Compliance |
ISO certified, FDA-friendly ingredients |
ISO/GMP certified, FDA-friendly ingredients |
Suitable for global export and B2B distribution |
| Recommended Storage |
Cool, dry, dark place; moisture-proof packaging |
Cool, dry place; airtight containers |
Shelf life may reduce if exposed to heat or humidity |
| Shelf Life |
24 months |
18–24 months |
Retains potency under proper storage conditions |
*Notes for Formulators
Capsules: S-equol powder can be blended with excipients like microcrystalline cellulose or magnesium stearate for smooth filling. Hard or soft capsules are suitable.
Gummies: Dissolve or disperse S-equol in the gelatin or pectin solution; may combine with vitamins, antioxidants, or natural extracts. Ensure uniform mixing to maintain consistent dosage.
Safety & Quality Control: Test final product for homogeneity, microbiological safety, and S-equol content per serving.
Contact Us for Wholesale Orders
Wholesale S-equol Powder good quality white powder by Peptidchem anti-aging ingredients and advanced delivery technologies. We provide one-stop production services for raw material sourcing for health supplement brands, distributors, and importers. Contact us now!
FAQs:
Q1: What is the minimum order quantity (MOQ)?
A1: Typically 25kg for trial orders; 50–1ton for bulk orders.
Q2: Can you provide certificates for export?
A2: Yes, we provide Certificate of Analysis (CoA), MSDS, and ISO compliance documents.
Q3: Is this product safe for food and cosmetic applications?
A3: Yes, S-equol is produced under food-grade and cosmetic-grade standards, compliant with international safety regulations.
Q4: How should the product be shipped?
A4: Usually by sea or air in moisture-proof packaging. Customs documents can be provided for smooth import.
Q5: Can you provide custom packaging or private label services?
A5: Yes, we offer OEM services and can customize packaging according to your requirements.
References
Crawford SL, Jackson EA, Churchill L, Lampe JW, Leung K, Ockene JK. Impact of dose, frequency of administration, and equol production on efficacy of isoflavones for menopausal hot flashes: a pilot randomized trial. Menopause. 2013 Sep;20(9):936-45.
Jenks BH, Iwashita S, Nakagawa Y, Ragland K, Lee J, Carson WH, Ueno T, Uchiyama S. A pilot study on the effects of S-equol compared to soy isoflavones on menopausal hot flash frequency. J Womens Health (Larchmt). 2012 Jun;21(6):674-82. doi: 10.1089/jwh.2011.3153.
Utian WH, Jones M, Setchell KD. S-equol: A Potential Nonhormonal Agent for Menopause-Related Symptom Relief. J Womens Health (Larchmt). 2015 Mar;24(3):200-8.
